What is TDF?

Tenofovir disoproxil fumarate (tenofovir DF or TDF) is a prescription drug approved by the U.S. Food and Drug Administration to be used with other HIV-1 medicines to treat and prevent HIV-1 infection. Tenofovir DF belongs to a group of drugs called nucleoside reverse transcriptase inhibitors, which work by blocking an enzyme to prevent HIV from multiplying and can reduce its presence in the body.1

TDF is also used with emtricitabine (TDF/FTC) for preexposure prophylaxis (PrEP) to prevent HIV infection for people at risk for acquiring HIV.

Truvada and other TDF drugs have been associated with serious side effects, including kidney and bone problems.1

What are the risks associated with TDF medications?

Serious possible side effects of TRUVADA, TRUVADA PrEP, and other TDF HIV medications include2:

  • New or worsening kidney problems, including kidney failure:
  • Bone problems: Including bone pain, softening or thinning of bones (osteopenia), which can lead to fractures
  • Lactic acidosis: A buildup of lactic acid in the blood, which can be life-threatening
  • Severe liver problems, which can be life-threatening